Chemical Name |
Nociceptin |
CAS Number |
170713-75-4 |
MDL Number |
MFCD05861378 |
Molecular Formula |
C79H129N27O22 |
Molecular Weight |
1809.04 |
Synonyms |
Orphanin FQ |
Introduction of 170713-75-4 :
Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic. In Vitro: Nociceptin (1 μg/mL) significantly prevents LPS (10 ng/mL)-stimulated cell migration whereas it is ineffective when added alone. Nociceptin (1 nM-10 μM) elicits a concentration-dependent blockade of LPS-mediated cell migration, with a maximal effect at 1 and 10 μM. Nociceptin counteracts LPS-induced elevation of IL-1β mRNA levels. Nociceptin (1 μM) and NNC 55-0396 induce apoptotic cell death in U87 cells. Nociceptin (1 μM) counteracts LPS-induced [Ca2+]i increase in U87 cells via β-arrestin 2. Nociceptin counteracts the LPS-induced phosphorylation of PKC and ERK in U87 cells. Nociceptin inhibits the LPS-mediated transcriptional activation of NF-kB and AP-1 reporter genes[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.