Chemical Name |
Bucladesine (sodium) |
CAS Number |
16980-89-5 |
MDL Number |
MFCD00005843 |
Molecular Formula |
C18H23N5NaO8P |
Molecular Weight |
491.37 |
Synonyms |
Dibutyryl cAMP (sodium salt);DBcAMP (sodium salt) |
Introduction of 16980-89-5 :
Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing[1][2][3][4]. IC50 & Target: PKA[1]
Phosphodiesterase (PDE)[4] In Vitro: Both choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA increased approximately fourfold after treatment of PC12 cells with Bucladesine (dibutyryl cyclic AMP; dbcAMP). ChAT and PKA activity are also increased by Bucladesine[5]. In Vivo: Intrahippocampal infusion of Bucladesine into the CA1 region (male Albino-Wistar rats) can cause an improvement in spatial memory in maze task. Bilateral infusion of 10 μM and 100 μM Bucladesine leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory). Bucladesine via activation of PKA and induction of cAMP/PKA pathway improved spatial memory retention[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.