Chemical Name |
OPC-28326 |
CAS Number |
167626-17-7 |
MDL Number |
MFCD13152377 |
Molecular Formula |
C26H38ClN3O3 |
Molecular Weight |
476.05 |
Introduction of 167626-17-7 :
OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively. IC50 & Target: Ki: 2040 nM (α2A adrenoceptor), 285 nM (α2B adrenoceptor), 55 nM (α2C adrenoceptor)[2] In Vitro: OPC-28326 enhances endothelial tube formation and promotes microvessel growth. OPC-28326 induces phosphorylation of eNOS and Akt in HAECs in a dose dependent-manner, while it does not affect total amounts of eNOS and Akt[1]. OPC-28326 (1-100 μM) and yohimbine (10-1000 nM) causes a rightward shift in the concentration-response curve of clonidine[2]. In Vivo: OPC-28326 augments blood flow recovery in murine hindlimb ischemia. OPC-28326 significantly increases the number of histologically detectable capillaries in the ischemic leg. OPC-28326 has no beneficial effects on blood flow recovery in eNOS−/− mice[1]. OPC-28326 (3-30 mg/kg, i.v.) and yohimbine causes dose-dependent rightward shift in the pressor dose-response curve induced by B-HT 920. OPC-28326 does not affect on the mydriasis in rats[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.