Chemical Name |
BMS-191095 |
CAS Number |
166095-21-2 |
MDL Number |
MFCD00953840 |
Molecular Formula |
C22H22Cl2N4O2 |
Molecular Weight |
445.34 |
Introduction of 166095-21-2 :
BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. Target: potassium channel in vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.