Brevilin A
| Chemical Name | Brevilin A |
|---|---|
| CAS Number | 16503-32-5 |
| MDL Number | MFCD04034623 |
| Molecular Formula | C20H26O5 |
| Molecular Weight | 346.42 |
Introduction of 16503-32-5 :
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26[1][2]. IC50 & Target: IC50: 10.6 µM (STAT3 signaling)[1]
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.