CAS No. 1637739-82-2, BQU57


NLT 98%

Bulk Quote Request

Chemical Name BQU57
CAS Number 1637739-82-2
Molecular Formula C16H13F3N4O
Molecular Weight 334.30
Introduction of 1637739-82-2 :

BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. The IC50 for BQU57 of 2.0 μM in H2122 and 1.3 μM in H358. IC50 value: 2.0 μM (H2122 cell), 1.3 μM (H358 cell) Target: Ral in vitro: BQU57 inhibits Ral binding to its effector RalBP1, Ral-mediated cell spreading in murine fibroblasts and anchorage-independent growth of human cancer cell lines. in vivo: H2122 xenograft tumors are collected 3h after a single intraperitoneal injection BQU57 (10/20/50 mg/kg) and activation of Ral in the extracts is analyzed in RalBP1 pull-down assays. Both RalA and RalB are significantly inhibited by BQU57. By contrast, no inhibition of Ras and RhoA activity is observed.

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

Bulk Quote Request