Z-Ile-Leu-aldehyde
161710-10-7
DY528781
C20H30N2O4
362.46
Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII
| Chemical Name | Z-Ile-Leu-aldehyde |
|---|---|
| CAS Number | 161710-10-7 |
| MDL Number | MFCD04974201 |
| Molecular Formula | C20H30N2O4 |
| Molecular Weight | 362.46 |
| Synonyms | Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII |
Introduction of 161710-10-7 :
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2]. In Vitro: Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2]. In Vivo: Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment[2].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.