Chemical Name |
Hemin |
CAS Number |
16009-13-5 |
MDL Number |
MFCD00010726 |
Molecular Formula |
C34H42ClFeN4O4 |
Molecular Weight |
662.02 |
Synonyms |
Hemin chloride |
Introduction of 16009-13-5 :
Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer. IC50 & Target: Heme oxygenase[1] In Vitro: Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment[1]. In Vivo: Following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.