FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo^[1][2][3]. IC50 & Target: p38 MAPK^[1] In Vivo: FR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis^[1].