Chemical Name |
Nitroflurbiprofen |
CAS Number |
158836-71-6 |
MDL Number |
MFCD00871245 |
Molecular Formula |
C19H20FNO5 |
Molecular Weight |
361.36 |
Synonyms |
HCT 1206;NO-flurbiprofen;Nitroxybutyl flurbiprofen |
Introduction of 158836-71-6 :
Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats. IC50 & Target: cyclooxygenase (COX)[1] In Vivo: In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.