Terodiline is an M1-selective muscarinic receptor (mAChR) antagonist with K_bs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline also is a Ca²⁺ blocker. Terodiline acts as a treatment for urinary frequency and urge incontinence^[1]. IC50 & Target: mAChR^[1]
Ca²⁺ channel^[1] In Vivo: Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID₅₀= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED₅₀=59 mg/kg)^[1].