Chemical Name |
Inogatran |
CAS Number |
155415-08-0 |
MDL Number |
MFCD00921988 |
Molecular Formula |
C21H38N6O4 |
Molecular Weight |
438.56 |
Synonyms |
H-314-27 |
Introduction of 155415-08-0 :
Inogatran (H-314-27) is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases. In Vivo: Inogatran (H-314-27; 0.075, 0.25, 0.75 mg/kg, i.v.) results in dose-dependent increases in activated partial thromboplastin time (aPTT), thrombin time (TT), and prothrombin time (PT) in a canine electrolytic injury model of venous thrombosis[1].
Inogatran dose-dependently inhibits thrombus formation, which is measured as an increase in time to occlusion (TTO) and a decrease in thrombus weight. Inogatran also improves vena caval blood flow and reduces the overall incidence of thrombotic occlusion in a rat model[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.