Chemical Name |
3-Oxo-5β-cholanoic acid |
CAS Number |
1553-56-6 |
Molecular Formula |
C24H38O3 |
Molecular Weight |
374.56 |
Synonyms |
Dehydrolithocholic acid;3-oxoLCA |
Introduction of 1553-56-6 :
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1]. In Vitro: Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity[1]. In Vivo: 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.