Chemical Name |
Clasto-Lactacystin β-lactone |
CAS Number |
154226-60-5 |
MDL Number |
MFCD07369253 |
Molecular Formula |
C10H15NO4 |
Molecular Weight |
213.23 |
Synonyms |
β-Clastolactacystin; β-Lactacystin; Omuralide |
Introduction of 154226-60-5 :
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor. IC50 & Target: 20S proteasome[1] In Vitro: Clasto-Lactacystin β-lactone is a natural active metabolite of lactacystin, which is a metabolite of Streptomyces. Clasto-Lactacystin β-lactone is the cell cycle progression in an osteosarcoma cell line[1]. Clasto-Lactacystin β-lactone is an irreversible 20S proteasome inhibitor, and also acts as a partial inhibitor of branched amino acid preferring peptidase (BrAAP). β-Lactone inactivates approximately 60% of the BrAAP activity rapidly, and the remaining 40% of the BrAAP activity is inactivated by β-lactone at a 50-fold slower rate[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.