Chemical Name |
Carmustine |
CAS Number |
154-93-8 |
MDL Number |
MFCD00057706 |
Molecular Formula |
C5H9Cl2N3O2 |
Molecular Weight |
214.05 |
Introduction of 154-93-8 :
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA. IC50 & Target: DNA Alkylator[1] In Vitro: Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 µM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct[1]. In Vivo: Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.