Chemical Name |
Nolatrexed dihydrochloride |
CAS Number |
152946-68-4 |
MDL Number |
MFCD00917041 |
Molecular Formula |
C14H14Cl2N4OS |
Molecular Weight |
357.26 |
Synonyms |
AG 337;Thymitaq |
Introduction of 152946-68-4 :
Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2]. IC50 & Target: Ki: 11 nM (Human Thymidylate Synthase)[1]
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.