Chemical Name |
Nalfurafine |
CAS Number |
152657-84-6 |
MDL Number |
MFCD09837714 |
Molecular Formula |
C28H32N2O5 |
Molecular Weight |
476.56 |
Synonyms |
TRK-820 |
Introduction of 152657-84-6 :
Nalfurafine (TRK-820) is a potent selective and orally active G protein-biased kappa opioid receptor (KOR)-agonist with high translational potential[1]. Nalfurafine (TRK-820) enhances the therapeutic potential of MOR-targeting analgesics, has the potential for uremic pruritis treatment[2]. IC50 & Target: IC50: kappa opioid receptor (KOR)[1] In Vivo: Nalfurafine (subcutaneous injection; 0.015 mg/kg) combines with EOM-salvinorin-B produces spinal antinociception equivalent to 5 mg/kg, it also enhances the supraspinal analgesic effect of 5 mg/kg morphine[1].
Nalfurafine (subcutaneous injection; 4 μg/kg) causes a dose-dependent increase of the inhibition of the acetic acid-induced abdominal constriction,and the inhibition of the abdominal constriction reaches its peak 30 min after injection, gradually declined and returned to the preinjection level 4 hr after[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.