Chemical Name |
Sapacitabine |
CAS Number |
151823-14-2 |
MDL Number |
MFCD00919466 |
Molecular Formula |
C26H42N4O5 |
Molecular Weight |
490.64 |
Synonyms |
CS682;CYC682 |
Introduction of 151823-14-2 :
Sapacitabine is an orally available nucleoside analog prodrug that is structurally related to cytarabine. IC50 & Target: nucleoside analog[1] In Vitro: Concentrations of Sapacitabine required to achieve an IC50 range from 3±0.6 μM for the colon cancer cell line HCT116 to 67±14 μM for the breast cancer cell line MDA-MB-435. Cell cycle analysis shows that 35% Sapacitabine-treated cells are arrested in late-S phase and 41% in G2/M phase. L1210 cells with deoxycytidine kinase (dCK) activity are sensitive to Sapacitabine, (IC50 20±6 μM). In the docetaxel/Sapacitabine combinations, synergistic effects (CI<1) are observed when docetaxel is given before Sapacitabine in both cell lines[1]. In Vivo: On Day 14, the Sapacitabine (5 mg/kg)+vorinostat (33 mg/kg) group has a mean tumour volume of 245 mm3 and a tumour growth inhibition (TGI) of 92%, whereas the Sapacitabine (15 mg/kg)+vorinostat (33 mg/kg) group has a mean tumour volume of 107 mm3 and a TGI of 112%[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.