Chemical Name |
(Rac)-Acolbifene |
CAS Number |
151533-34-5 |
MDL Number |
MFCD09837712 |
Molecular Formula |
C29H31NO4 |
Molecular Weight |
457.56 |
Synonyms |
EM-343;(Rac)-EM-652 |
Introduction of 151533-34-5 :
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380[1]. In Vitro: (Rac)-Acolbifene (EM-343; (Rac)-EM-652) shows a inhibitory effect in T-47D cells with an IC50 value of 0.110 nM[1].
In Vivo: (Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice)[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.