Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM. IC50 & Target: IC50: 5 nM (SAMDC)^[1] In Vitro: Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control^[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells^[2].