MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1] IC50:29.3 (src), 2.5 uM (syk); [1] In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]