Chemical Name |
Desethyl chloroquine |
CAS Number |
1476-52-4 |
MDL Number |
MFCD00871808 |
Molecular Formula |
C16H22ClN3 |
Molecular Weight |
291.82 |
Introduction of 1476-52-4 :
Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2]. In Vitro: P. falciparum[1] In Vivo: Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.