ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease^[1][2]. IC50 & Target: nAChRs^[1][2] In Vivo: ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze^[1].
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment^[1].
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD^[2].
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression^[2].