Chemical Name |
Tritoqualine |
CAS Number |
14504-73-5 |
MDL Number |
MFCD00865662 |
Molecular Formula |
C26H32N2O8 |
Molecular Weight |
500.54 |
Synonyms |
Inhibostamin;Hypostamine |
Introduction of 14504-73-5 :
Tritoqualine is used as a histidine decarboxylase inhibitor. IC50 & Target: histidine decarboxylase[1] In Vitro: The effect of Tritoqualine (TRQ) on the CCl4-induced enzyme leakage is investigated by pretreatment of rats with Tritoqualine (200 mg/kg/day, p.o., 7 days). The ratio of lactate dehydrogenase (LDH) release from the cells of Tritoqualine-pretreated rats is significantly less than that in control rats. The rate of malondialdehyde (MDA) production is accelerated after the addition of 7.8 mM CCl4. Tritoqualine reduces its rate in a dose dependent manner, and it completely prevents CCl4-stimulated lipid peroxidation at a concentration of 33 μM[2]. In Vivo: A single administration of CCl4 (0.75 mL/kg, p.o.) causes a five-fold increase of in vivo lipid peroxidation in the liver. In contrast, a reduction of 37% in the lipid peroxidation is obtained by Tritoqualine (100 mg/kg) pretreatment for 14 days prior to CCl4 treatment. A 63% reduction is observed in vitamin E (25 mg/kg) pretreated rats[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.