CAS No. 145-63-1, Suramin

Suramin

NLT 98%
145-63-1
DY524363
C51H34N6Na6O23S6
1429.17

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Chemical Name Suramin
CAS Number 145-63-1
MDL Number MFCD00210217
Molecular Formula C51H34N6Na6O23S6
Molecular Weight 1429.17
Introduction of 145-63-1 :

Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin is an antitrypanosomal, anti-neoplastic and anti-angiogenic agent[5][6][7]. In Vitro: Suramin (50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells[6].
Suramin (300 μg/mL; for 48 hours) induces cells apoptosis, and down-regulates mRNA expression in HeLa cells[6].
Suramin (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2[7].
The IC50 values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively[6].
In Vivo: Suramin (10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure[7].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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