CAS No. 14484-47-0, Deflazacort

Deflazacort

NLT 98%
14484-47-0
DY524286
C25H31NO6
441.52

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Chemical Name Deflazacort
CAS Number 14484-47-0
MDL Number MFCD00866106
Molecular Formula C25H31NO6
Molecular Weight 441.52
Introduction of 14484-47-0 :

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. Target: Glucocorticoid Receptor Deflazacort is an inactive prodrug which is converted rapidly to the active metabolite 21-desacetyldeflazacort. Maximum concentrations of 21-desacetyldeflazacort averaged 116 ng/ml and were observed after 1.3 h. The average area under the curve was 280 ng/ml.h, and the terminal half-life was 1.3 h. 21-Desacetyldeflazacort was cleared significantly faster than both methylprednisolone and prednisolone [1]. Two of 40 boys treated with deflazacort died at 13 and 18 years of age from cardiac failure. The treated boys were significantly shorter, did not have excessive weight gain and 22 of 40 had asymptomatic cataracts. Deflazacort has a very significant impact on health, quality of life and health care costs for boys with DMD and their families, and is associated with few side effects [2].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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