Chemical Name |
Olmesartan |
CAS Number |
144689-24-7 |
MDL Number |
MFCD10567132 |
Molecular Formula |
C24H26N6O3 |
Molecular Weight |
450.53 |
Synonyms |
RNH-6270 |
Introduction of 144689-24-7 :
Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure[1][2]. In Vitro: Olmesartan (0.7-5 mM; 24, 48 and 72 h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode[3]. In Vivo: Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks[1]. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.