Chemical Name |
Tin-protoporphyrin IX |
CAS Number |
14325-05-4 |
MDL Number |
MFCD00673909 |
Molecular Formula |
C34H46Cl2N4O4Sn |
Molecular Weight |
764.37 |
Synonyms |
SnPPIX |
Introduction of 14325-05-4 :
Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1]. IC50 & Target: IC50: Heme oxygenase-1 (HO-1)[1] In Vitro: Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1].
In Vivo: Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.