5-(N,N-Hexamethylene)-amiloride
| Chemical Name | 5-(N,N-Hexamethylene)-amiloride |
|---|---|
| CAS Number | 1428-95-1 |
| MDL Number | MFCD00069211 |
| Molecular Formula | C12H18ClN7O |
| Molecular Weight | 311.77 |
| Synonyms | Hexamethylene amiloride;HMA |
Introduction of 1428-95-1 :
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2]. IC50 & Target: Na+/H+ exchanger[1]
EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2]
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.