Chemical Name |
Parbendazole |
CAS Number |
14255-87-9 |
MDL Number |
MFCD00864534 |
Molecular Formula |
C13H17N3O2 |
Molecular Weight |
247.29 |
Synonyms |
SKF 29044 |
Introduction of 14255-87-9 :
Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity. IC50 & Target: EC50: 8.79 nM (tubulin)[1] In Vitro: Parbendazole is a tubulin destabilizer, with an EC50 of 8.79 nM, and can induce DNA damage[1]. Parbendazole (2-10 μM) inhibits the assembly of microtubules dose-dependently, with an IC50 of 3 μM. Parbendazole (2-20 μM)-treated cells show an complete absence of microtubules in Vero cells[2]. Parbendazole (up to 10 μM) inhibits the growth of CLd-AXE myxamoebae. Parbendazole (2-5 μM) potently inhibits tubulin purified from the wild-type myxamoebae[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.