Chemical Name |
ZM241385 |
CAS Number |
139180-30-6 |
MDL Number |
MFCD00908394 |
Molecular Formula |
C16H15N7O2 |
Molecular Weight |
337.34 |
Introduction of 139180-30-6 :
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3]. IC50 & Target: Ki: 1.4 nM (A2AR)[2] In Vitro: ZM241385 (1 μM; 24 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA levels[1].
ZM241385 (1 μM; 48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly increases A2AR protein levels[1]. In Vivo: ZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC[4].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.