Chemical Name |
Zanamivir |
CAS Number |
139110-80-8 |
MDL Number |
MFCD00866966 |
Molecular Formula |
C12H20N4O7 |
Molecular Weight |
332.31 |
Introduction of 139110-80-8 :
Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively. IC50 & Target: IC50: 0.95 nM (Influenza A); 2.7 nM (Influenza B)[1] In Vitro: Zanamivir interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions[2]. In Vivo: Zanamivir has a poor bioavailability in oral administration, with only 4–17% of the agent. Oral delivery of zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.