CAS No. 138605-00-2, NKH477


NLT 98%
Colforsin dapropate hydrochloride

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Chemical Name NKH477
CAS Number 138605-00-2
MDL Number MFCD00236421
Molecular Formula C27H44ClNO8
Molecular Weight 546.09
Synonyms Colforsin dapropate hydrochloride
Introduction of 138605-00-2 :

NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1]. IC50 & Target: Adenylate Cyclase[1] In Vivo: NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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