CAS No. 13860-66-7, N3PT


NLT 98%
N3-pyridyl thiamine

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Chemical Name N3PT
CAS Number 13860-66-7
MDL Number MFCD22572771
Molecular Formula C13H14Cl4N2
Molecular Weight 340.08
Synonyms N3-pyridyl thiamine
Introduction of 13860-66-7 :

N3PT(N3-pyridyl thiamine) is a potent and selective transketolase(TK) inhibitor (IC50= 22 nM for Apo-TK) both in vitro and in vivo. IC50 Value: 22 nM( Apo-TK) ; 26 nM (EC50, Cellular TK) [1] Target: transketolase in vitro: N3PT inhibits transketolase activity in a cell based assay. Competitive inhibition of TK by N3PT in cells treated with increasing doses of thiamine, expressed as percentage enzymatic activity (the slope of initial linear range) of controls not treated with compounds [1]. in vivo: Tumors were induced in mice at day 0 and mice were then treated at day 7 with vehicle alone or with N3PT [2]. Low-thiamine diet enhances the sensitivity to N3PT inhibition of TK in spleen. Animals were switched to diets containing 16.5 mg/kg (unchanged), 5 mg/kg, 1 mg/kg, or 0 mg/kg thiamine, from a normal chow containing 16.5mg/kg thiamine [1].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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