Introduction of 138-86-3 :

Limonene is a monoterpene in citrus peel oil. A popular disinfectant and food preservative. Antimicrobial activities^[1]. Anti-proliferative activities^[2]. Antioxidant and anti-inflammatory effect^[3]. IC50 & Target: Bacterial^[1] In Vitro: Acute toxicity to limonene is largely due to the common oxidation product limonene-hydroperoxide. The mutant protein AhpCL177Q 35 is able to alleviate this toxicity by reducing the hydroperoxide to a more benign compound^[1].

Limonene exerts anti-proliferative action on a lymphoma cell line without modifying normal lymphocyte viability^[2].

In Vivo: Limonene (50-100 mg/kg) exerts gastroprotection through local mucosal defense mechanisms, such as increasing the mucus production, modulation of the oxidative stress and inflammatory response and inhibition of Nf-κb expression ^[3].