CAS No. 138-52-3, Salicin


NLT 98%

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Chemical Name Salicin
CAS Number 138-52-3
MDL Number MFCD00006590
Molecular Formula C13H18O7
Molecular Weight 286.28
Synonyms D-(−)-Salicin;Salicoside
Introduction of 138-52-3 :

Salicin is a natural COX inhibitor. IC50 & Target: COX[1] In Vitro: Significant down regulation of PGE2, the enzymatic product of COX2, to 76% in lysate and 70% in supernatant is observed with Salicin 10 μM treatment in COLO cells when compare to the COLO control. This is accompanied with a minimal COX1 inhibition to 91% of the CCD control on the genetic level. Treatment with Salicin 1 μM decreases colon cancer cell proliferation rates from 144% to 113% at 24 hours and 187% to 130% at 48 hours, with 10 μM decreasing proliferation rates to 108% at 24 hours and 119% at 48 hours[1]. The concentrations of TNF-α, IL-1β and IL-6 of LPS-induced cells pretreated with 0.07, 0.14 and 0.28 μM Salicin are significant reduced compare with LPS group[2]. In Vivo: Salicin (D(-)-Salicin) (35, 70, 140 μM) markedly inhibits the LPS-induced pathological changes. MPO activity in LPS-induced lung tissue is significantly increased compare with control group. However, Salicin (35, 70, 140 μM) markedly inhibits this change. Pretreatment with Salicin inhibits LPS-induced activation of JNK, ERK, p38/MAPK and p65 in a dose-dependent manner[2].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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