Chemical Name |
Salicin |
CAS Number |
138-52-3 |
MDL Number |
MFCD00006590 |
Molecular Formula |
C13H18O7 |
Molecular Weight |
286.28 |
Synonyms |
D-(−)-Salicin;Salicoside |
Introduction of 138-52-3 :
Salicin is a natural COX inhibitor. IC50 & Target: COX[1] In Vitro: Significant down regulation of PGE2, the enzymatic product of COX2, to 76% in lysate and 70% in supernatant is observed with Salicin 10 μM treatment in COLO cells when compare to the COLO control. This is accompanied with a minimal COX1 inhibition to 91% of the CCD control on the genetic level. Treatment with Salicin 1 μM decreases colon cancer cell proliferation rates from 144% to 113% at 24 hours and 187% to 130% at 48 hours, with 10 μM decreasing proliferation rates to 108% at 24 hours and 119% at 48 hours[1]. The concentrations of TNF-α, IL-1β and IL-6 of LPS-induced cells pretreated with 0.07, 0.14 and 0.28 μM Salicin are significant reduced compare with LPS group[2]. In Vivo: Salicin (D(-)-Salicin) (35, 70, 140 μM) markedly inhibits the LPS-induced pathological changes. MPO activity in LPS-induced lung tissue is significantly increased compare with control group. However, Salicin (35, 70, 140 μM) markedly inhibits this change. Pretreatment with Salicin inhibits LPS-induced activation of JNK, ERK, p38/MAPK and p65 in a dose-dependent manner[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.