CAS No. 1373422-53-7, GSK-J1


NLT 98%

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Chemical Name GSK-J1
CAS Number 1373422-53-7
MDL Number MFCD22683851
Molecular Formula C22H23N5O2
Molecular Weight 389.45
Introduction of 1373422-53-7 :

GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B.  IC50 & Target: IC50: 60 nM (KDM6B)[2] In Vitro: GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner[1]. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC50 of 11 μM and 94 μM, respectively[3].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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