GSK-J1
| Chemical Name | GSK-J1 |
|---|---|
| CAS Number | 1373422-53-7 |
| MDL Number | MFCD22683851 |
| Molecular Formula | C22H23N5O2 |
| Molecular Weight | 389.45 |
Introduction of 1373422-53-7 :
GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B. IC50 & Target: IC50: 60 nM (KDM6B)[2] In Vitro: GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner[1]. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC50 of 11 μM and 94 μM, respectively[3].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.