Chemical Name |
RG14620 |
CAS Number |
136831-49-7 |
MDL Number |
MFCD00236445 |
Molecular Formula |
C14H8Cl2N2 |
Molecular Weight |
275.13 |
Synonyms |
Tyrphostin RG14620 |
Introduction of 136831-49-7 :
RG14620 is an EGFR inhibitor with an IC50 of 3 μM. IC50 & Target: IC50: 3 μM (EGFR)[1] In Vitro: RG14620 inhibits colony formation (IC50=3 μM) and DNA synthesis (IC50=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50=4 μM) and DNA synthesis (IC50=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible[2]. In Vivo: RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.