Chemical Name |
PD 123319 (ditrifluoroacetate) |
CAS Number |
136676-91-0 |
MDL Number |
MFCD11046022 |
Molecular Formula |
C35H36F6N4O8 |
Molecular Weight |
754.67 |
Introduction of 136676-91-0 :
PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. IC50 & Target: IC50: 34 nM (AT2 Receptor)[1] In Vitro: PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.