Chemical Name |
Timosaponin BII |
CAS Number |
136656-07-0 |
MDL Number |
MFCD11111457 |
Molecular Formula |
C45H76O19 |
Molecular Weight |
921.07 |
Synonyms |
Prototimosaponin A III |
Introduction of 136656-07-0 :
Timosaponin BII is an antioxidant and an anti-inflammatory agent. In Vitro: Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1]. In Vivo: Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.