Fidarestat
| Chemical Name | Fidarestat |
|---|---|
| CAS Number | 136087-85-9 |
| MDL Number | MFCD00919183 |
| Molecular Formula | C12H10FN3O4 |
| Molecular Weight | 279.22 |
| Synonyms | SNK 860 |
Introduction of 136087-85-9 :
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. IC50 & Target: IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)[1] In Vitro: Fidarestat is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively[1]. In Vivo: Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats[2].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.