ML-210
| Chemical Name | ML-210 |
|---|---|
| CAS Number | 1360705-96-9 |
| MDL Number | MFCD22666407 |
| Molecular Formula | C22H20Cl2N4O4 |
| Molecular Weight | 475.32 |
Introduction of 1360705-96-9 :
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2]. IC50 & Target: Glutathione Peroxidase 4 (GPX4)[1] In Vitro: ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4[1].
ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.