Chemical Name |
Piperoxan (hydrochloride) |
CAS Number |
135-87-5 |
MDL Number |
MFCD00079224 |
Molecular Formula |
C14H20ClNO2 |
Molecular Weight |
269.77 |
Synonyms |
Benodaine hydrochloride |
Introduction of 135-87-5 :
Piperoxan hydrochloride is an α2 adrenoceptor antagonist. IC50 & Target: adrenoceptor[1] In Vitro: When the medulla is superfused with α2 adrenoceptor antagonist Piperoxane (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF), the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxane applications (163±12% of the previous mean frequency). In active medullary preparations, the effects of NA applications (25 μM; 5 min) are compared when the preparations sre superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxane (50 μM; PIP-ACSF; n=5). NA applications either alone (NA-ACSF) or with Piperoxane (PIP-ACSF+NA) significantly increases the phrenic burst frequency. However, the blockage of the medullary α2 adrenoceptors by Piperoxane potentiates a phrenic burst frequency increase: during the fifth minute of NA applications, the phrenic burst frequency reached 171±11% of the mean control value when ACSF is applied alone and 234±21% of the mean control value when PIP-ACSF is applied in control condition[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.