Chemical Name |
Revizinone |
CAS Number |
133718-29-3 |
MDL Number |
MFCD00867129 |
Molecular Formula |
C26H29N5O3 |
Molecular Weight |
459.54 |
Synonyms |
R80122 |
Introduction of 133718-29-3 :
Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. target: phosphodiesterase (PDE)[3]; IC 50: 0.036 microM; [3] In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) was 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increased global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [4]
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.