Chemical Name |
Flavopiridol (Hydrochloride) |
CAS Number |
131740-09-5 |
MDL Number |
MFCD05860967 |
Molecular Formula |
C21H21Cl2NO5 |
Molecular Weight |
438.30 |
Synonyms |
Alvocidib (Hydrochloride);L86-8275 (Hydrochloride);HMR-1275 (Hydrochloride) |
Introduction of 131740-09-5 :
Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively. IC50 & Target: IC50: 30 nM (CDK1), 170 nM (CDK2), 100 nM (CDK4)[3] In Vitro: Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases[1]. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.