Chemical Name |
NBTGR |
CAS Number |
13153-27-0 |
MDL Number |
MFCD01119046 |
Molecular Formula |
C17H18N6O6S |
Molecular Weight |
434.43 |
Introduction of 13153-27-0 :
NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM. IC50 & Target: Ki: 70 nM (adenosine uptake)[1] In Vitro: A group of purine ribonucleosides with alkarylmercapto substituents at the purine 6-position are potent inhibitors of several aspects of nucleoside metabolism that involved the transfer of ribosyl groups. NBTGR is one of the compounds that inhibits nucleoside transport by human erythrocytes; initial rates of uridine uptake are reduced to zero upon exposure of cells to 1 μM NBTGR. The inhibitor is firmly bound because repeated washing cannot restore uridine transport capability to NBTGR-treated cells. NBTGR inhibits the influx of uridine, inosine, and cytidine, without inhibiting the uptake of the corresponding bases, or that of D-glucose or L-leucine. Uridine antagonizes the NBTGR inhibition of uidine transport in a concentration-dependent manner. NBTGR and related compounds appear to interact with the mechanism for the facilitated transport of nucleosides[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.