Chemical Name |
Neticonazole |
CAS Number |
130726-68-0 |
MDL Number |
MFCD00868954 |
Molecular Formula |
C17H22N2OS |
Molecular Weight |
302.43 |
Introduction of 130726-68-0 :
Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole has anti-infection and anti-cancer effects[1][2][3]. IC50 & Target: Fungal [1]
Exosome secretion[2] In Vitro: Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels[2].
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells[2]. In Vivo: Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.