Chemical Name |
SKF-96365 (hydrochloride) |
CAS Number |
130495-35-1 |
MDL Number |
MFCD00236407 |
Molecular Formula |
C22H27ClN2O3 |
Molecular Weight |
402.91 |
Introduction of 130495-35-1 :
SKF-96365 hydrochloride is a non-selective TRP Channel blocker. IC50 & Target: TRP Channel[1] In Vitro: SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner[1]. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects[2]. In Vivo: SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.