Chemical Name |
L-655708 |
CAS Number |
130477-52-0 |
MDL Number |
MFCD02684528 |
Molecular Formula |
C18H19N3O4 |
Molecular Weight |
341.36 |
Introduction of 130477-52-0 :
L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM). IC50: 0.45 nM (Ki) Target: GABA in vitro: L-655708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 orα6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity. in vivo: L-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment.[1]
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.