Chemical Name |
Mivotilate |
CAS Number |
130112-42-4 |
MDL Number |
MFCD02752797 |
Molecular Formula |
C12H14N2O3S3 |
Molecular Weight |
330.45 |
Synonyms |
YH439 |
Introduction of 130112-42-4 :
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent. IC50 & Target: Aryl hydrocarbon receptor[1] In Vitro: Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine[1]. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor[3]. In Vivo: Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.